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We need to challenge “what is clinically relevant weight loss”?
By Dr Sean Wharton, MD, PharmD, FRCP(C)
Internal Medicine Specialist
Adjunct Professor
McMaster University and York University, Ontario, Canada
Diplomat of the American Board of Obesity Medicine
By Dr Sean Wharton, MD, PharmD, FRCP(C)
Internal Medicine Specialist
Adjunct Professor
McMaster University and York University, Ontario, Canada
Diplomat of the American Board of Obesity Medicine
Weight management is about addressing the complications of overweight and obesity, many of which are primarily managed with sustained weight loss. Although many discussions surround the fact that minimal weight loss is beneficial for a number of medical conditions, it is clear to me that for many complications, more than 5% weight loss is needed to see a clinically relevant benefit.1,4 Prevention of diabetes starts at 3% weight loss, yet this improves significantly with losses greater than 5%.1,3 Diabetes remission requires 10 to 15% weight loss.1,3 Conditions such as obstructive sleep apnea and osteoarthritis also require more weight loss than 5%.1
When we ask patients about their weight loss expectations, they state that they expect 30% weight loss.5 Although that much weight loss is often considered an unreasonable expectation for strategies outside of bariatric surgery, we question patients for considering such lofty goals. The medical field disagrees with such high expectations primarily due to the fact that there have been no interventions, outside of bariatric surgery, that can attain this amount of weight loss over the long term. We blame the patient for expecting too much. We should blame the lack of effective non-surgical interventions for not getting us to that goal.
Patients should expect enough weight loss to correct their weight-related complications and that is, in most cases, more than 5%, as documented by the majority of studies looking at clinically relevant improvements or even resolution of complications related to obesity.1,4 Obesity medicine specialists should stop pretending that 5% is enough, and when all the available interventions are capable of achieving over 10% weight loss in patients, it is likely that they will.
We championed 5% weight loss as the reasonable goal, likely due to
the fact that 5% was all that could be achieved in the long term with
the most commonly used non-surgical treatments such as lifestyle
intervention. We should no longer accept long term weight loss of 5%
as a minimum standard. The necessity of needing more weight loss - and
the need for more effective medication in weight management - is
evident. Current anti-obesity medications can enable weight loss
beyond 5%. We need to challenge current standards of clinically
relevant weight loss to achieve real improvements in weight-related
complications and our patients deserve that level of
intervention.
References
HQ21OB00117, Approval date: July 2021
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